The S-IIIs underwent enhancement procedures similar to those of the Spartan-IIs, but with higher success rates due to the advances in technology. The rate of survival went up from 44% for the Spartan-IIs to 100% for the S-IIIs. The augmentation procedures were referred to as Project CHRYSANTHEMUM. The S-III's were injected with the following drugs:
- Drug 8942-LQ99: A carbide ceramic ossification catalyst to make skeletons virtually unbreakable.
- Drug 88005-MX77: A fibroid muscular protein complex that boosted muscle density and strength.
- Drug 88947-OP24: A retina-inversion stabilizer drug. It boosted color and night vision capabilities.
- Drug 87556-UD61: Improved colloidal neural dis-unification solution, which in turn decreases reaction time.
In addition, the following drugs were injected into the Spartans of Gamma Company. They were illegal, but Kurt-051 felt that they were necessary for the Spartans to survive in battle.
- Drug 009762-OO: a mutagen that alters key regions of the subject's frontal lobe. It enhances aggression, strength, endurance, and tolerance to injury, which allowed fighting when they should be dead or in a coma. Negative effects include a loss in rational thinking and tactics. This is counter-balanced by the anti-psychotic and bipolar-integration drugs listed below.
- Drug 009927-DG: Miso-olanzapine. An anti-psychotic. This drug counters the mutagen's properties.
- Drug 009127-PX: Cyclodexione-4. A bipolar-integration drug. Counters the mutagen's properties.
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